Benign or cancerous tumors seen in the PPB tumor predisposition syndrome include:

• PPB
• Lung cysts
• Cystic nephroma
• Nodular thyroid hyperplasia/thyroid adenomas
• Ovarian Sertoli-Leydig tumor, juvenile granulosa cell tumor and gynandroblastoma
• Embryonal rhabdomyosarcoma
• Neuroblastoma
• Wilms tumor
• Nephrogenic rests
• Papillary thyroid carcinoma
• Medulloblastoma and other childhood CNS tumors
• Nasal chondromesenchymal hamartoma
• Small bowel polyps (juvenile type/hamartomatous)

Some families may have individuals with one or more of these conditions and no history of PPB. Individuals with any of these conditions may be eligible for the NCI study.