Benign or cancerous tumors seen in the PPB tumor predisposition syndrome include:

  • PPB
  • Lung cysts
  • Cystic nephroma
  • Nodular thyroid hyperplasia/thyroid adenomas
  • Ovarian Sertoli-Leydig tumor, juvenile granulosa cell tumor and gynandroblastoma
  • Embryonal rhabdomyosarcoma
  • Neuroblastoma
  • Wilms tumor
  • Nephrogenic rests
  • Papillary thyroid carcinoma
  • Medulloblastoma and other childhood CNS tumors
  • Nasal chondromesenchymal hamartoma
  • Small bowel polyps (juvenile type/hamartomatous)

Some families may have individuals with one or more of these conditions and no history of PPB. Individuals with any of these conditions may be eligible for the NCI study.


Washington University Barnes Jewish Hospital Siteman Cancer Center
Children's Hospital

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